Paper on astrocyte-derived metamodulation accepted for publication

David and Matt’s work demonstrating astrocyte-derived metamodulation, which involves interactions between adenosinergic and dopaminergic signalling within spinal motor circuits, has just been accepted for publication in the Journal of Neurophysiology.

Acton D., Broadhead M.J. & Miles, G. B. (2018). Modulation of spinal motor networks by astrocyte-derived adenosine is dependent on D1-like dopamine receptor signalling.  Journal of Neurophysiology (in press).

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Paper on dysregulation of AMPARs in C9ORF72 ALS accepted for publication in Nature Communications

A multi-centre paper we contributed to, which shows dysregulation of AMPAR expression in C9ORF72 ALS, has just been accepted for publication in Nature Communications. This paper includes Amit’s findings that ALS patient iPSC-derived motoneurons do not show dysfunctional phenotypes when grown in the absence of ALS-affected astrocytes.

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Review on gliotransmission in spinal motor circuits accepted for publication

David’s review on gliotransmission in spinal motor circuits has just been accepted for publication in the Journal of Neurophysiology.

Acton D. & Miles, G. B. (2017). Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks. Journal of Neurophysiology (in press).

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Fully-funded PhD studentship available to study role of Na pumps in health and disease

We are currently looking for applicants for a new fully-funded PhD studentship to continue our work (Picton et al., J Neurosci, 2017) investigating the roles of Na pumps in healthy and MND-affected spinal neurons using human iPSC-derived neurons and animal models.

For further information see the advertisement or contact Dr Gareth Miles.

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Looking for PhD student to study human sensory neurons

The NCM lab is currently seeking applicants for a new PhD project investigating the physiology of human sensory (dorsal root ganglion) neurons.

For more info and application details go to:
http://www.eastscotbiodtp.ac.uk/validation-and-functional-characterisation-primary-sensory-neurons-derived-adult-human-dorsal-root

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NMDA receptor co-agonists and spinal circuits – paper accepted

David’s work on the roles of NMDA receptor co-agonists, D-serine and glycine, within spinal motor circuits has just been accepted for publication in the Journal of Neurophysiology.

Acton D. & Miles, G. B. (2017). Differential regulation of NMDA receptors by D-serine and glycine in mammalian spinal locomotor networks.  Journal of Neurophysiology (in press).

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Na pump paper ‘featured article’ in The Journal of Neuroscience

Laurence, Filipe and Matt’s work on the role of Na pumps in spinal motor networks has been published in the latest issue of the Journal of Neuroscience where it has also been highlighted in the “This Week in the Journal” editorial section.

L.D. Picton, F. Nascimento, M.J. Broadhead, K.T. Sillar, & G.B. Miles (2017). Sodium pumps mediate activity-dependent changes in mammalian motor networks. The Journal of Neuroscience, 37(4):906-921. [Link]

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Looking for new PhD student to study MND using iPSC-based models

The NCM lab is currently seeking applicants for a PhD project associated with the new Scotland-wide SPRINT-MND/MS scheme. See below for more details about the scheme and links.

Link to specific NCM lab project here.

“Applications are now open for SPRINT-MND/MS: a new Scotland-wide PhD scheme for research into motor neurone disease and multiple sclerosis. Projects, encompassing a wide range of topics including laboratory, clinical, and social sciences, are available at Aberdeen, Dundee, Edinburgh, Glasgow and St Andrews Universities. The studentships include stipend, fees, consumables/travel and structured opportunities for patient/public engagement. The deadline for applications is 20th January 2017. For more information, see www.edneurophd.ed.ac.uk/sprint-mndms-phd-programme.”

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Sodium pumps and motor control – paper accepted

Laurence, Filipe and Matt’s work on the role of sodium pumps in mammalian spinal motor networks has just been accepted for publication in The Journal of Neuroscience.

Picton, L. D., Nascimento, F., Broadhead, M. J., Sillar, K. T., & Miles, G. B. (2016). Sodium pumps mediate activity-dependent changes in mammalian motor networks. The Journal of Neuroscience (in press).

 

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Mr G’s MND Fun Run 2016

Mr G’s MND Fun Run 2016 was another huge success and a fantastic day!  Thanks to all the runners, supporters and volunteers. And of course a massive thank you to Donald, Brynja and their families!

For more info and pictures of the day go to:  https://www.facebook.com/MrGsMND5kmFunRun/

Mr_Gs_Fun_Run_2016_thanks

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