Author Archives: Gareth Miles

Paper on synaptic mechanisms at cholinergic, C-bouton synapses accepted for publication

Work from Filipe, Matt, and our collaborators in Athens, which reveals synaptic mechanisms underlying the modulatory influence of cholinergic C-bouton synapses on motoneuron output, has been accepted for publication by eLife. The paper entitled “Synaptic mechanisms underlying modulation of locomotor-related … Continue reading

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Paper on signalling between neurons and astrocytes in spinal circuits accepted for publication

Matt’s work, which reveals bi-directional signalling mechanisms between neutrons and astrocytes within spinal motor circuits has been accepted for publication by Frontiers in Cellular Neuroscience. The paper entitled “Bi-directional Communication Between Neurons and Astrocytes Modulates Spinal Motor Circuits ” will … Continue reading

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Paper showing that C9orf72 (ALS) astrocytes cause pathophysiology in motoneurons accepted for publication

Work from Anna-Claire, Amit, Veronica and our collaborators in Edinburgh, which reveals pathophysiology in human iPSC-derived motoneurons caused by iPSC-derived astrocytes harbouring C9orf72 mutations, has been accepted for publication in Glia. The paper is entitled “Mutant C9orf72 human iPSC-derived astrocytes cause … Continue reading

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Paper on balanced cholinergic modulation accepted for publication

Filipe’s work, which reveals a balance in cholinergic modulation of spinal motor circuits due to the opposing actions of M2 and M3 muscarinic receptors, has been accepted for publication in Scientific Reports. The paper entitled “Balanced cholinergic modulation of spinal locomotor … Continue reading

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Paper on astrocyte-derived metamodulation accepted for publication

David and Matt’s work demonstrating astrocyte-derived metamodulation, which involves interactions between adenosinergic and dopaminergic signalling within spinal motor circuits, has just been accepted for publication in the Journal of Neurophysiology. Acton D., Broadhead M.J. & Miles, G. B. (2018). Modulation of … Continue reading

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Paper on dysregulation of AMPARs in C9ORF72 ALS accepted for publication in Nature Communications

A multi-centre paper we contributed to, which shows dysregulation of AMPAR expression in C9ORF72 ALS, has just been accepted for publication in Nature Communications. This paper includes Amit’s findings that ALS patient iPSC-derived motoneurons do not show dysfunctional phenotypes when … Continue reading

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Review on gliotransmission in spinal motor circuits accepted for publication

David’s review on gliotransmission in spinal motor circuits has just been accepted for publication in the Journal of Neurophysiology. Acton D. & Miles, G. B. (2017). Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks. Journal of Neurophysiology (in … Continue reading

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Fully-funded PhD studentship available to study role of Na pumps in health and disease

We are currently looking for applicants for a new fully-funded PhD studentship to continue our work (Picton et al., J Neurosci, 2017) investigating the roles of Na pumps in healthy and MND-affected spinal neurons using human iPSC-derived neurons and animal … Continue reading

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Looking for PhD student to study human sensory neurons

The NCM lab is currently seeking applicants for a new PhD project investigating the physiology of human sensory (dorsal root ganglion) neurons. For more info and application details go to: http://www.eastscotbiodtp.ac.uk/validation-and-functional-characterisation-primary-sensory-neurons-derived-adult-human-dorsal-root

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NMDA receptor co-agonists and spinal circuits – paper accepted

David’s work on the roles of NMDA receptor co-agonists, D-serine and glycine, within spinal motor circuits has just been accepted for publication in the Journal of Neurophysiology. Acton D. & Miles, G. B. (2017). Differential regulation of NMDA receptors by … Continue reading

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