Work from Anna-Claire, Amit, Veronica and our collaborators in Edinburgh, which reveals pathophysiology in human iPSC-derived motoneurons caused by iPSC-derived astrocytes harbouring C9orf72 mutations, has been accepted for publication in Glia.
The paper is entitled “Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology”.
Filipe’s work, which reveals a balance in cholinergic modulation of spinal motor circuits due to the opposing actions of M2 and M3 muscarinic receptors, has been accepted for publication in Scientific Reports.
The paper entitled “Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors” is due to be published by Scientific Reports on the 1st of October 2019.
David and Matt’s work demonstrating astrocyte-derived metamodulation, which involves interactions between adenosinergic and dopaminergic signalling within spinal motor circuits, has just been accepted for publication in the Journal of Neurophysiology.
Acton D., Broadhead M.J. & Miles, G. B. (2018). Modulation of spinal motor networks by astrocyte-derived adenosine is dependent on D1-like dopamine receptor signalling. Journal of Neurophysiology (in press).
A multi-centre paper we contributed to, which shows dysregulation of AMPAR expression in C9ORF72 ALS, has just been accepted for publication in Nature Communications. This paper includes Amit’s findings that ALS patient iPSC-derived motoneurons do not show dysfunctional phenotypes when grown in the absence of ALS-affected astrocytes.
David’s review on gliotransmission in spinal motor circuits has just been accepted for publication in the Journal of Neurophysiology.
Acton D. & Miles, G. B. (2017). Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks. Journal of Neurophysiology (in press).
We are currently looking for applicants for a new fully-funded PhD studentship to continue our work (Picton et al., J Neurosci, 2017) investigating the roles of Na pumps in healthy and MND-affected spinal neurons using human iPSC-derived neurons and animal models.
For further information see the advertisement or contact Dr Gareth Miles.
The NCM lab is currently seeking applicants for a new PhD project investigating the physiology of human sensory (dorsal root ganglion) neurons.
For more info and application details go to:
David’s work on the roles of NMDA receptor co-agonists, D-serine and glycine, within spinal motor circuits has just been accepted for publication in the Journal of Neurophysiology.
Acton D. & Miles, G. B. (2017). Differential regulation of NMDA receptors by D-serine and glycine in mammalian spinal locomotor networks. Journal of Neurophysiology (in press).
Laurence, Filipe and Matt’s work on the role of Na pumps in spinal motor networks has been published in the latest issue of the Journal of Neuroscience where it has also been highlighted in the “This Week in the Journal” editorial section.
L.D. Picton, F. Nascimento, M.J. Broadhead, K.T. Sillar, & G.B. Miles (2017). Sodium pumps mediate activity-dependent changes in mammalian motor networks. The Journal of Neuroscience, 37(4):906-921. [Link]
The NCM lab is currently seeking applicants for a PhD project associated with the new Scotland-wide SPRINT-MND/MS scheme. See below for more details about the scheme and links.
Link to specific NCM lab project here.
“Applications are now open for SPRINT-MND/MS: a new Scotland-wide PhD scheme for research into motor neurone disease and multiple sclerosis. Projects, encompassing a wide range of topics including laboratory, clinical, and social sciences, are available at Aberdeen, Dundee, Edinburgh, Glasgow and St Andrews Universities. The studentships include stipend, fees, consumables/travel and structured opportunities for patient/public engagement. The deadline for applications is 20th January 2017. For more information, see www.edneurophd.ed.ac.uk/sprint-mndms-phd-programme.”