Broadhead MJ, Bonthron C, Waddington J, Smith W V, Lopez MF, Burley S, Valli J, Zhu F, Komiyama NH, Smith C, Grant SGN, Miles GB (2022) Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis. Acta Neuropathologica 143471–486 [link].


Sharples SA, Miles GB (2021). Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development. eLife 10:e71385. doi: 10.7554/eLife.71385 [link].

Strother L, Miles GB, Holiday AR, Cheng Y, Doherty GH (2021). Long-term culture of SH-SY5Y neuroblastoma cells in the absence of neurotrophins: a novel model of neuronal ageing. J Neurosci Methods, Jul;57:109301 [link].

Broadhead MJ, Miles GB (2021). A common role for astrocytes in rhythmic behaviours? Progress in Neurobiology202:102052. [link].


Broadhead MJ, Bonthron C, Arcinas L, Bez S, Zhu F, Goff FE, Nylk J, Dholakia K, Gunn-Moore FJ, Grant SGN, Miles GB (2020). Nanostructural Diversity of Synapses in the Mammalian Spinal Cord. Scientific Reports10:8189 [link].

Nascimento F, Broadhead MJ, Tetringa E, Tsape E, Zagoraiou L, Miles GB (2020). Synaptic mechanisms underlying modulation of locomotor-related motoneuron output by premotor cholinergic interneurons. eLife. 9:e54170, doi: 10.7554/eLife.54170 [link].

Broadhead MJ and Miles GB (2020). Bi-directional communication between neurons and astrocytes modulates spinal motor circuits. Frontiers in Cellular Neuroscience. 14, 14 p., 30; doi: 10.3389/fncel.2020.00030 [link].

Zhao C, Devlin AC, Chouhan AK, Selvaraj BT, Stavrou M, Burr K, Brivio V, He X, Mehta AR, Story D, Shaw CE, Dando O, Hardingham GE, Miles GB, Chandran S (2020). Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology. Glia. 68(5):1046-1064 [link].

Schubert M, Woolfson L, Barnard IRM, Dorward A, Casement B, Morton A, Robertson GB, Appleton PL, Miles GB, Tucker CS, Pitt SJ, Gather MC (2020). Monitoring contractility in single cardiomyocytes and whole hearts with bio-integrated microlasers.   Nature Photonics 14 (7), 452-458 [link].


Nascimento F, Spindler LRB, Miles GB (2019). Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors. Scientific Reports, 9:14051 [link].

Rozani I, Tsapara G, Witts EC, Deaville SJ, Miles GB, and Zagoraiou L (2019). Pitx2 cholinergic interneurons are the source of C bouton synapses on brainstem motor neurons. Scientific Reports, 9:4936 [link].

Morton A, Murawski C, Deng Y, Keum C, Miles GB, Tello JA, Gather MC (2019). Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes. Advanced Biosystems, 1800290, DOI: 10.1002/adbi.201800290 [Link].

Miles GB, Wyart C (2019) Editorial overview: Motor control systems of the spinal cord and hindbrain. Curr Opin Physiol 8:iii–v [Link].


D. Acton, M.J. Broadhead & G.B. Miles (2018). Modulation of spinal motor networks by astrocyte-derived adenosine is dependent on D1-like dopamine receptor signalling.  Journal of Neurophysiology, 120:998-1009 [Link].

Thangaraj Selvaraj , B. , Livesey , M. , Zhao , C. , Gregory , J. , James, O. , Cleary, E. , Chouhan, A. K. , Gane, A. , Perkins, E. , Dando, O. , Lillico, S. , Lee, Y. , Nishimura, A. , Poreci, U. , Thankamony, S. , Pray, M. , Vasistha, N. , Magnani, D. , Borooah, S. , Burr, K. Story, D., McCampbell, A., Shaw, C., Kind, P., Aitman, T., Whitelaw, B., Wilmut, I., Smith, C., Miles, G. B., Hardingham, G., Wyllie, D. & Chandran, S (2018). C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+ -permeable AMPA receptor-mediated excitotoxicity. Nature Communications, 9(1):347. doi: 10.1038/s41467-017-02729-0 [Link].


D. Acton & G.B. Miles (2017). Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks. Journal of Neurophysiology, 118: 3311–3327 [Link].

D. Acton and G.B. Miles (2017). Differential regulation of NMDA receptors by D-serine and glycine in mammalian spinal locomotor networks. Journal of Neurophysiology, 117(5): [Link].

L.D. Picton, F. Nascimento, M.J. Broadhead, K.T. Sillar, & G.B. Miles (2017). Sodium pumps mediate activity-dependent changes in mammalian motor networks. Journal of Neuroscience, 37(4):906-921. [Link]
* Article featured in “This Week in the Journal” editorial section. [Link]

M. Schubert, K. Volckaert, M. Karl, A. Morton, P. Liehm, G.B. Miles, S.J Powis, & M.C. Gather (2017). Lasing in live mitotic and non-phagocytic cells by efficient delivery of microresonators. Scientific Reports, 7:40877. [Link]


A. Steude, E.C. Witts, G.B. Miles, M.C. Gather (2016). Arrays of microscopic organic LEDs for high-resolution optogenetics. Science Advances, 2(5). [Link]


E.C. Witts, F. Nascimento and G.B. Miles (2015). Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice. Journal of Neurophysiology, 114(4):2305-15.. [Link]

D. Acton and G.B. Miles (2015). Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine. PLoS ONE, 10(8): e0134488. doi:10.1371/journal.pone.0134488. [Link]

A.C. Devlin, K. Burr, S. Borooah, J. D. Foster, E. M. Cleary, I. Geti, L. Vallier, C. E. Shaw, S. Chandran and G. B. Miles (2015). Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Nature Communications, 6:5999 doi:10.1038/ncomms6999. [Link]


J.D. Foster, C. Dunford, K.T. Sillar, G.B. Miles (2014). Nitric Oxide-Mediated Modulation of the Murine Locomotor Network. Journal of Neurophysiology, 111:659-74. [Link]

E.C. Witts, L. Zagoraiou, G.B. Miles (2014). Anatomy and function of cholinergic, C-bouton, inputs to motoneurons. Journal of Anatomy, 224:52-60. [Link]


M. Antkowiak, M.L. Torres, E.C. Witts, G.B. Miles,  K. Dholakia, F.J. Gunn-Moore (2013) Fast targeted gene transfection and optogenetic modification of single neurons using femtosecond laser irradiation. Scientific Reports, 3, 3281, 8p. [Link]


L.R. Herron and G.B. Miles (2012). Gender -specific perturbations in modulatory inputs to motoneurons in a mouse model of Amyotrophic Lateral Sclerosis. Neuroscience, 226:313-323. [Link]

E. C. Witts, K. M. Panetta, G. B. Miles (2012). Glial-derived adenosine modulates spinal motor networks in mice. Journal of Neurophysiology, 107(7):1925-34. [Link]


G.B. Miles and K.T. Sillar (2011). Neuromodulation of vertebrate locomotor control networks. Physiology, 26:(6) 393-411. [Link]

N. Iwagaki and G.B. Miles (2011). Activation of group I metabotropic glutamate receptors modulates locomotor-related motoneuron output in mice. Journal of Neurophysiology, 105(5): 2108-20. [Link]

Neuron cover


L. Zagoraiou, T. Akay, J.F. Martin, R.M. Brownstone, T.M. Jessell, G.B. Miles (2009) A cluster of cholinergic pre-motor interneurons modulates mouse locomotor activity. Neuron, 64(5): 645-662. [Link]
* Featured on cover of issue and in preview article: “A New Class of Spinal Interneurons: The Origin and Function of C Boutons Is Solved” E. Frank , 64(5): 593-595, 2009.


D.C. Yohn, G.B. Miles, V.F. Rafuse, R.M. Brownstone (2008). Transplanted mouse embryonic stem cell-derived motoneurons form functional motor units and reduce muscle atrophy. Journal of Neuroscience, 28(47):12409-12418. [Link]
* Article featured in “This Week in the Journal” editorial section.

K. Mukhida, M. Hong, G.B. Miles, T. Phillips, B.A. Baghbaderani, M. McLeod, N. Kobayashi, A. Sen, L.A. Behie, R. M. Brownstone, I. Mendez (2008). A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain, 131, 2106-2126. [Link]


G.B. Miles, R. Hartley, A.J. Todd, R.M. Brownstone (2007). Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion. Proceedings of the National Academy of Sciences of the United States of America, 104(7):2448-2453. [Link]
* Faculty of 1000 Biology evaluation: “Must Read” article (Serge Rossignol: Faculty of 1000 Biology, 11 Mar 2008


L. Ma, H. Ostrovsky, G.B. Miles, J. Lipski, G.D. Funk and L.F.B. Nicholson (2006). Differential expression of Group I metabotropic glutamate receptors in human motoneurons at low and high risk of degeneration in ALS. Neuroscience, 143(1):95-104. [Link]

P. Soundararajan, G.B. Miles, L.L. Rubin, R.M. Brownstone, and V.F. Rafuse (2006). Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. Journal of Neuroscience, 26(12):3256-3268. [Link]
* Article featured in “This Week in the Journal” editorial section.


G.B. Miles, Y. Dai, R.M. Brownstone (2005). Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurons. Journal of Physiology (London) 566(2): 519-532. [Link]

T. Adachi, D.M. Robinson, G.B. Miles, G.D. Funk (2005). Noradrenergic modulation of XII motoneuron inspiratory activity does not involve {alpha}2 receptor inhibition of the Ih current or presynaptic glutamate release. Journal of Applied Physiology, 98(4):1297-308. [Link]


G.B. Miles, D.C. Yohn, H. Wichterle, T.M. Jessell, V.F. Rafuse, R.M. Brownstone (2004). Functional properties of motoneurons derived from mouse embryonic stem cells. Journal of Neuroscience, 24(36):7848-58. [Link]

G.B. Miles, J. Lipski, A.R. Lorier, P. Laslo, G.D. Funk (2004). Differential expression of voltage-activated calcium channels in III and XII motoneurones during development in the rat. European Journal of Neuroscience, 20(4):903-913. [Link]


G.B. Miles, M.A. Parkis, J. Lipski, G.D. Funk (2002). Modulation of phrenic motoneuron excitability by ATP: consequences for respiratory-related output in vitro. Journal of Applied Physiology 92(5):1899-910. [Link]


P. Laslo, J. Lipski, L.F.B. Nicholson, G.B. Miles, G.D. Funk (2001). GluR2 AMPA receptor subunit expression in motoneurons at low and high risk for degeneration in Amyotrophic Lateral Sclerosis. Experimental Neurology 169:461-471. [Link]


P. Laslo, J. Lipski, L.F.B. Nicholson, G.B. Miles, G.D. Funk (2000). Calcium binding proteins in motoneurons at low and high risk for degeneration in ALS. Neuroreport 11:3305-3308. [Link]

G.D. Funk, M.A. Parkis, S.R. Selvaratnam, D.R. Robinson, G.B. Miles, K. Peebles (2000). Synaptic control of motoneuronal excitability across multiple time scales in rodents: from months to milliseconds. Clinical and Experimental Pharmacology and Physiology 27:120-125. [Link]